21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T538,Bone morphogenetic protein (BMP)2/7 heterodimer shows greater efficacy in enhancing bone regeneration. However, the precise mechanism and the role of mitogen-activated protein kinase (MAPK) signaling network in BMP2/7-driven osteogenesis remain ambiguous. In this study, we evaluated the effects of BMP2/7 heterodimers on osteoblastic differentiation in rat bone marrow mesenchymal stem cells (BMSCs), with the aim to elaborate how MAPKs might be involved in this cellular process by treatment of rat BMSCs with BMP2/-7 with a special signal-pathway inhibitor. We found that BMP2/7 heterodimer induced a much stronger osteogenic response in rat BMSCs compared with either homodimer. Most interestingly, extracellular signal-regulated kinase (ERK) demonstrated a highly sustained phosphorylation and activation in the BMP2/7 heterodimer treatment groups, and inhibition of ERK cascades using U0126 special inhibitor that significantly reduced the activity of ALP and calcium mineralization to a substantial degree in rat BMSCs treated with BMP2/7 heterodimers. Collectively, we demonstrate that BMP2/7 heterodimer shows a potent ability to stimulate osteogenesis in rat BMSCs. The activated ERK signaling pathway involved in this process may contribute partially to an increased osteogenic potency of heterodimeric BMP2/7 growth factors.23:T548,Metal-organic frameworks (MOFs) have attracted great attention as templates for preparation of functional porous materials owing to their adjustable structures, rich porosity, and controllable components. However, collapsed templates during the conversion process hinder their application and synthesis of derivatives. In this study, we demonstrate a novel two-step etching strategy during which amorphous MOF microspheres are initially transformed into nickel hydroxide and then subsequently transformed into microspherical nickel phosphates. Through this strategy, the prepared nickel phosphates maintain the microspherical morphology of MOFs but with no MOF residuals, exhibiting ultrahigh specific surface area, uniform pore size, and good structural robustness. Examined as a supercapacitor electrode, they show an outstanding specific capacity of 820 C g^-1 at 0.5 A g^-1 and remarkable cycling stability of 88% capacity retention after 10 000 cycles. Moreover, an asymmetric supercapacitor constructed utilizing reduced graphene cross-linked with p-phenylenediamine oxide (PPD-rGO) as the cathode displays a preeminent energy density of 64.56 Wh kg^-1 at a power density of 507 W kg^-1. This strategy has important significance in guiding the preparation of high-performance MOF-derived electrodes.24:T66c,

#	Concept	H-Index	Publications	Citations
1	Medicine	2	2	39
2	Cell Biology	2	2	39
3	Cellular Physiology	1	1	18
4	Immunology	1	1	18
5	Pharmacology	1	1	18

	Year	Citations

About

Top Concepts