Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

Pia Leete, Abby Willcox, Lars Krogvold, +4

Diabetes

Insulitis OccurImmunodeficienciesImmunologyPathologyPancreas Transplantation +18

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

Lars Krogvold, Bjørn Edwin, Trond Buanes, +16

Diabetes

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

Sarah J. Richardson, Teresa Rodríguez-Calvo, Ivan Gerling, +11

Diabetologia

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Federica Vecchio, Nicola Lo Buono, Angela Stabilini, +20

JCI Insight

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Máikel L. Colli, Jessica L. Hill, Laura Marroquí, +14

EBioMedicine

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Mark A. Russell, Sambra D. Redick, David M. Blodgett, +17

Diabetes

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

Máikel L. Colli, Mireia Ramos-Rodríguez, Ernesto Nakayasu, +19

Nature Communications

Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes

Marcus Lundberg, Lars Krogvold, Enida Kuric, +2

Diabetes

T-regulatory CellImmunologyImmunologic MechanismInnate ImmunityImmunotherapy +16

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

Lars Krogvold, Oskar Skog, Görel Sundström, +7

Diabetes

Type 1Diabetes Virus DetectionInsulin ManagementPhysiologyImmunology +10

Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes

Lars Krogvold, Anna Wiberg, Bjørn Edwin, +7

Diabetologia

Type 1Pancreatic Fluid CollectionDiabetesImmunologyPathology +4