Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, +16

Cancer Discovery

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Mary Ann Anderson, Constantine S. Tam, Thomas E. Lew, +9

Blood

Enrichment of BTK Leu528Trp mutations in patients with CLL on zanubrutinib: potential for pirtobrutinib cross-resistance

Piers Blombery, Ella R. Thompson, Thomas E. Lew, +9

Blood Advances

Hematological MalignancyBtk Leu528trp MutationOncologyMedicineMixed-phenotype Acute Leukemia +13

BTK inhibitor therapy is effective in patients with CLL resistant to venetoclax

Victor S. Lin, Thomas E. Lew, Sasanka M. Handunnetti, +8

Blood

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, +19

Blood

Bcl2 FamilyMixed-phenotype Acute LeukemiaImmunologyImmunotherapyTumor Biology +24

Clonal hematopoiesis, myeloid disorders and <i>BAX</i>-mutated myelopoiesis in patients receiving venetoclax for CLL

Piers Blombery, Thomas E. Lew, Michael A. Dengler, +15

Blood

Hematological MalignancySimultaneous Bcl2 MutationsOncologyAcute Myeloid LeukemiaMalignant Blood Disorder +12

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Thomas E. Lew, Victor S. Lin, Edward R. Scheffer Cliff, +10

Blood Advances

Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months

Thomas E. Lew, Mary Ann Anderson, Victor S. Lin, +8

Blood Advances

Attainment PlateausMixed-phenotype Acute LeukemiaImmunologyPathologyPharmacotherapy +16

Rasburicase Causing Severe Oxidative Hemolysis and Methemoglobinemia in a Patient with Previously Unrecognized Glucose-6-Phosphate Dehydrogenase Deficiency

Chan Y. Cheah, Thomas E. Lew, John F. Seymour, +1

Acta Haematologica

Metabolic DisorderPathologyRedox BiologyAplastic AnemiaOxidative Stress +14

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Alice P.S. Kong, Thomas E. Lew, Eric S. H. Lau, +12

Diabetes Obesity and Metabolism