Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

Irene Chiolo, Aki Minoda, Serafin U. Colmenares, +3

Cell

ChromatinGenome InstabilityDynamic Hp1a DomainChromatin StructureChromatin Remodeling +11

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

Carole L. Yauk, Aris Polyzos, Andrea Rowan‐Carroll, +9

Proceedings of the National Academy of Sciences

Germ-line MutationsGeneticsAir QualityEpigeneticsGlobal Hypermethylation +14

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

Aris Polyzos, Do Yup Lee, Rupsa Datta, +12

Cell Metabolism

Molecular NeuroscienceNeurophysiologyMetabolic ReprogrammingNeurochemical BiomarkersNeurology +8

Sidestream tobacco smoke is a male germ cell mutagen

Francesco Marchetti, Andrea Rowan‐Carroll, Andrew Williams, +3

Proceedings of the National Academy of Sciences

Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes

Aris Polyzos, Amy Holt, Christopher Brown, +6

Human Molecular Genetics

MitophagyNovel Synthetic AntioxidantLipid PeroxidationOxidative DamageImmunology +20

Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action

Carole L. Yauk, Aris Polyzos, Andrea Rowan‐Carroll, +3

Environmental and Molecular Mutagenesis

Tandem Repeat MutationEpigenetic ChangeGeneticsDna MethylationGlobal Dna Methylation +14

Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling

Jonathan Tang, Heiko Enderling, Sabine Becker-Weimann, +4

Integrative Biology

Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse

Aris Polyzos, Thomas E. Schmid, Ana Belem Piña-Guzmán, +2

Toxicology and Applied Pharmacology

SpermatogenesisTobacco ControlGerm CellTobacco UseTobacco Smoke +6

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

Aris Polyzos, Nigel I. Wood, Paul D. Williams, +3

PLoS ONE

Slow Onset ModelSevere ModelEnergy HomeostasisDisease PhenotypeDevelopmental Biology +11

An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

Lila Lovergne, Dhruba Ghosh, Renaud Schuck, +6

Scientific Reports