Jeff Keats

Discovery of 3-[2-(Imidazo[1,2-<i>b</i>]pyridazin-3-yl)ethynyl]-4-methyl-<i>N</i>-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Wei‐Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi et al. · Journal of Medicinal Chemistry · 2010 · 362 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

Sen Zhang, Rana Anjum, Rachel M. Squillace et al. · Clinical Cancer Research · 2016 · 326 citations · Full text

Medicine, Oncology, Pharmacology +15

Structural Mechanism of the Pan‐BCR‐ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance

Tianjun Zhou, Lois Commodore, Wei‐Sheng Huang et al. · Chemical Biology & Drug Design · 2010 · 284 citations

Medicine, Oncology, Pharmacology +14

Crystal Structure of the T315I Mutant of Abl Kinase

Tianjun Zhou, Lois Parillon, Feng Li et al. · Chemical Biology & Drug Design · 2007 · 104 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine‐based Compounds

David C. Dalgarno, Thilo Stehle, Surinder S. Narula et al. · Chemical Biology & Drug Design · 2005 · 86 citations · Full text

Medicine, Medicinal Chemistry, Molecular Biology +17