Multiplexed genome regulation in vivo with hyper-efficient Cas12a

Lucie Y. Guo, Jing Bian, Alexander E. Davis, +12

Nature Cell Biology

Transcriptional RegulationLineage PlasticityGene RegulationMultiplexed Genome RegulationGene Expression +3

NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

Fang Fang, Pei Zhuang, Xue Feng, +10

Molecular Therapy

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

Liang Li, Fang Fang, Xue Feng, +8

Neuron

Ganglion CellPhotoreceptor CellDevelopmental BiologyMolecular NeuroscienceRetina +9

A NaAc-assisted large-scale coprecipitation synthesis and microwave absorption efficiency of Fe3O4 nanowires

Aiguo Yan, Yuejun Liu, Yong Liu, +3

Materials Letters

Materials ScienceChemical EngineeringFe3o4 NanowiresEngineeringNanomaterials +6

Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension

Fang Fang, Jie Zhang, Pei Zhuang, +9

Scientific Reports

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

Pingting Liu, Wei Chen, Haowen Jiang, +13

Molecular Therapy — Nucleic Acids

RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function

Fang Fang, Pingting Liu, Haoliang Huang, +5

Molecular Therapy — Nucleic Acids

Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells

Wei Chen, Pingting Liu, Dong Liu, +8

Nature Communications

Identification and Functional Analysis of a SLC33A1: c.339T>G (p.Ser113Arg) Variant in the Original SPG42 Family

Fei Mao, Zhaohui Li, Baoyue Zhao, +7

Human Mutation

EngineeringGeneticsMolecular BiologyGene CharacterizationMolecular Genetics +16

S113R mutation in Slc33a1 leads to neurodegeneration and augmented BMP signaling in a mouse model

Pingting Liu, Baichun Jiang, Jian Ma, +5

Disease Models & Mechanisms