A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

Nina Hanke, Denise Türk, Dominik Selzer, +7

Clinical Pharmacokinetics

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole

Denise Türk, Nina Hanke, Sarah Wolf, +4

Clinical Pharmacokinetics

Significant impact of time-of-day variation on metformin pharmacokinetics

Denise Türk, Nina Scherer, Dominik Selzer, +7

Diabetologia

Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N¹‐Methylnicotinamide: A PBPK Modeling Approach

Denise Türk, Fabian Müller, Martin F. Fromm, +3

Clinical Pharmacology & Therapeutics

A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies

Nina Hanke, Denise Türk, Dominik Selzer, +5

Pharmaceutics

Novel models for the prediction of drug–gene interactions

Denise Türk, Laura Maria Fuhr, Fatima Zahra Marok, +5

Expert Opinion on Drug Metabolism & Toxicology

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Predictions

Helena Leonie Hanae Loer, Denise Türk, José David Gómez‐Mantilla, +2

Pharmaceutics

A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

Denise Türk, Nina Hanke, Thorsten Lehr

Pharmaceutics