Tomoyasu Isobe

IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system

Keisuke Hagihara, Teppei Nishikawa, Tomoyasu Isobe et al. · Biochemical and Biophysical Research Communications · 2004 · 185 citations

Inflammation, Synergistic Induction, Cytokine +10

Enhanced Mdm2 activity inhibits pRB function via ubiquitin‐dependent degradation

Chiharu Uchida, Seiichi Miwa, Kyoko Kitagawa et al. · The EMBO Journal · 2004 · 180 citations · Full text

Essential role of STAT3 in cytokine‐driven NF‐κB‐mediated serum amyloid A gene expression

Keisuke Hagihara, Teppei Nishikawa, Yasuhiro Sugamata et al. · Genes to Cells · 2005 · 162 citations · Full text

Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients

Soken-Nakazawa J. Song, Mitsuhiro Iwahashi, Naohisa Tomosugi et al. · Arthritis Research & Therapy · 2013 · 136 citations · Full text

Transcriptional Complex Formation of c-Fos, STAT3, and Hepatocyte NF-1α Is Essential for Cytokine-Driven C-Reactive Protein Gene Expression

Teppei Nishikawa, Keisuke Hagihara, Satoshi Serada et al. · The Journal of Immunology · 2008 · 121 citations