Robert Opitz

A modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

Robert Opitz, Matthias Müller, Cédric Reuter et al. · Proceedings of the National Academy of Sciences · 2015 · 49 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Anup Arumughan, Yvette Roske, Carolin Barth et al. · Nature Communications · 2016 · 49 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Addressing Protein–Protein Interactions with Small Molecules: A Pro‐Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD‐Binding Ligands

Jan Zaminer, Christoph Brockmann, Peter Huy et al. · Angewandte Chemie International Edition · 2010 · 48 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Matthias Barone, Matthias Müller, Slim Chiha et al. · Proceedings of the National Academy of Sciences · 2020 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Efficient α‐Helix Induction in a Linear Peptide Chain by <i>N</i>‐Capping with a Bridged‐tricyclic Diproline Analogue

V.D. Hack, Cédric Reuter, Robert Opitz et al. · Angewandte Chemie International Edition · 2013 · 37 citations

Pharmacy, Biochemistry, Medicinal Chemistry +13