Concepedia

Author

Sean Shadle

Fred Hutch Cancer Center

Also Known As

Sean C Shadle, Sean C. Shadle, Sean Shadle, Shadle Sean C., Shadle, Sean

27

Publications

933

Citations

10

H-Index

26

Concepts

All Affiliations

Fred Hutch Cancer CenterLeiden University Medical CenterUniversity of WashingtonUniversity of UtahUniversity of Rochester Medical Center
SS

About

Sean Shadle is an author at Fred Hutch Cancer Center specializing in medicine, cell biology, and developmental biology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

4

4

388

2

Cell Biology

4

4

388

3

Cellular Physiology

2

2

204

4

Health Sciences

1

1

109

5

Natural Sciences

1

1

64

Sean Shadle

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10

Publications

859

Citations

10

H-Index

YearCitations

KDM5B regulates embryonic stem cell self‐renewal and represses cryptic intragenic transcription

Liangqi Xie, Carl Pelz, Wensi Wang,

The EMBO Journal

2011

173

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

Guo-Liang Chew, Amy E. Campbell, Emma De Neef,

Developmental Cell

2019

120

Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells

Sujatha Jagannathan, Sean Shadle, Rebecca Resnick,

Human Molecular Genetics

2016

115

p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

Edward J. Grow, B. D. Weaver, Christina M. Smith,

Nature Genetics

2021

109

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Sean Shadle, Jun Zhong, Amy E. Campbell,

PLoS Genetics

2017

95

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4

Judit Balog, Peter Thijssen, Sean Shadle,

Epigenetics

2015

69

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

Amy E. Campbell, Sean Shadle, Sujatha Jagannathan,

eLife

2018

64

BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

Amy E. Campbell, Jonathan Oliva, Matthew Yates,

Skeletal Muscle

2017

63

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double-stranded RNA foci in human cell models of FSHD

Sean Shadle, Sean Bennett, Chao-Jen Wong,

Human Molecular Genetics

2019

41

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD

Sean Shadle, Sean Bennett, Chao-Jen Wong,

2019

10

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