Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment

Jonathan M. Labriola, Akash Pandhare, Michaela Jansen, +3

Journal of Biological Chemistry

Membrane StructureBiochemistryMembrane TransportIon ChannelsMembrane Environment +4

The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors

Akash Pandhare, Aneesh Satya Pappu, Henrik Wilms, +2

Neuropharmacology

Antidepressant BupropionPsychiatryFunctional SelectivityMedicineSerotonin Type 3A +11

Bupropion Binds to Two Sites in the<i>Torpedo</i>Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analogue [¹²⁵I]-SADU-3-72

Akash Pandhare, Ayman K. Hamouda, Brandon Staggs, +7

Biochemistry

Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors

Nelli Mnatsakanyan, Sita Nirupama Nishtala, Akash Pandhare, +6

Biochemistry

Molecular BiologyCellular PhysiologyIntracellular DomainMolecular PharmacologyGlic-icd Chimeras +21

Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain

Sita Nirupama Nishtala, Nelli Mnatsakanyan, Akash Pandhare, +2

Journal of Neurochemistry

Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors

Akash Pandhare, Petar N. Grozdanov, Michaela Jansen

Scientific Reports

Delineating the Site of Interaction of the 5-HT3A Receptor with the Chaperone Protein RIC-3

Elham Pirayesh, Antonia G. Stuebler, Akash Pandhare, +1

Biophysical Journal

(±)-2-(N-tert-Butylamino)-3′-[125I]-iodo-4′-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)

David J. Lapinsky, Shaili Aggarwal, Tammy L. Nolan, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryDopamine TransporterMedicine +8

Photoaffinity labeling the agonist binding domain of α4β4 and α4β2 neuronal nicotinic acetylcholine receptors with [125I]epibatidine and 5[125I]A-85380

Ayman K. Hamouda, Xiaochun Jin, Mitesh Sanghvi, +5

Biochimica et Biophysica Acta (BBA) - Biomembranes

Molecular PharmacologyMolecular NeuroscienceBiochemistryMedicineNeurotransmitter +7

[3H]Epibatidine Photolabels Non-equivalent Amino Acids in the Agonist Binding Site of Torpedo and α4β2 Nicotinic Acetylcholine Receptors

Shouryadeep Srivastava, Ayman K. Hamouda, Akash Pandhare, +4

Journal of Biological Chemistry

Agonist Binding SiteAmino AcidsSynaptic TransmissionMolecular BiologyAlpha Subunits +16