Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

Erick J. Morris, Sharda Jha, Clifford R. Restaino, +40

Cancer Discovery

PharmacotherapyTumor BiologyDrug ResistanceMek InhibitorsReceptor Tyrosine Kinase +18

Crossover from Superexchange to Hopping as the Mechanism for Photoinduced Charge Transfer in DNA Hairpin Conjugates

Frederick D. Lewis, Huihe Zhu, Pierre Daublain, +4

Journal of the American Chemical Society

Hole Mobility in DNA A Tracts

Frederick D. Lewis, Huihe Zhu, Pierre Daublain, +2

Angewandte Chemie International Edition

Dna AnalysisMolecular BiologyMolecular GeneticsWhole SchemeDna Nanotechnology +14

Dynamics of Photochemical Electron Injection and Efficiency of Electron Transport in DNA

Pierre Daublain, Arun K. Thazhathveetil, Qiang Wang, +3

Journal of the American Chemical Society

EngineeringMolecular BiologyPhotochemical Electron InjectionExcitation Energy TransferElectron Injection +15

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

Xavier Pépin, Leon Aarons, Yuya Wang, +64

European Journal of Pharmaceutics and Biopharmaceutics

Pharmacokinetic ModelingPrediction AccuracyModelling StrategiesPredictive AnalyticsMedicine +7

Getting to guanine: mechanism and dynamics of charge separation and charge recombination in DNA revisited

Frederick D. Lewis, Huihe Zhu, Pierre Daublain, +5

Photochemical & Photobiological Sciences

ChromatinDna NanotechnologyNatural SciencesDna AnalysisOligonucleotide +8

Reversible Bridge-Mediated Excited-State Symmetry Breaking in Stilbene-Linked DNA Dumbbells

Frederick D. Lewis, Pierre Daublain, Ligang Zhang, +7

The Journal of Physical Chemistry B

Dna NanotechnologyExcited-state BehaviorPhotochemistryNatural SciencesStilbene-linked Dna Dumbbells +8

Dynamics and Efficiency of DNA Hole Transport via Alternating AT versus Poly(A) Sequences

Frederick D. Lewis, Pierre Daublain, Boiko Cohen, +3

Journal of the American Chemical Society

EngineeringDna AnalysisMolecular BiologySequence DesignCharge Transport +17

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer

Ryan V. Quiroz, Michael H. Reutershan, Sebastian E. Schneider, +34

Journal of Medicinal Chemistry

Dynamics and Mechanism of Bridge-Dependent Charge Separation in Pyrenylurea−Nitrobenzene π-Stacked Protophanes

Frederick D. Lewis, Pierre Daublain, Grace B. Delos Santos, +6

Journal of the American Chemical Society