Concepedia

Lyle W. Spruce

LW

Statistics

Publications

6

Citations

244

H-Index

6

Active since

1987

Affiliations

Cortech Solutions (United States)(Current)

University of Wisconsin–Madison

Oklahoma State University Oklahoma City

Oklahoma State University

Ono Pharmaceutical (Japan)

Lyle W. Spruce is an author at Cortech Solutions (United States) specializing in pharmacology, enzyme inhibition, and drug discovery.

Publications per year

1987–2001

6

Publications

6

Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

Kazuyuki Ohmoto, Tetsuya Yamamoto, Motohiro Okuma et al. · Journal of Medicinal Chemistry · 2001 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

Kazuyuki Ohmoto, Tetsuya Yamamoto, Toshihide Horiuchi et al. · Journal of Medicinal Chemistry · 2000 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Biologically Active Heteroarotinoids Exhibiting Anticancer Activity and Decreased Toxicity

Doris M. Benbrook, Matora M. Madler, Lyle W. Spruce et al. · Journal of Medicinal Chemistry · 1997 · 55 citations

Life Sciences, Oncology, Pharmacology +14

Novel heteroarotinoids: synthesis and biological activity

Lyle W. Spruce, Jonathan B. Gale, K. Darrell Berlin et al. · Journal of Medicinal Chemistry · 1991 · 30 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Heteroarotinoids. Synthesis, characterization, and biological activity in terms of an assessment of these systems to inhibit the induction of ornithine decarboxylase activity and to induce terminal differentiation of HL-60 cells

Lyle W. Spruce, Shirish N. Rajadhyaksha, K. Darrell Berlin et al. · Journal of Medicinal Chemistry · 1987 · 25 citations

Medicine, Biochemistry, Pharmacology +11

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