Scott E. Fix

Identification of the First <i>trans</i>-(3<i>R</i>,4<i>R</i>)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity

James B. Thomas, Robert N. Atkinson, Richard B. Rothman et al. · Journal of Medicinal Chemistry · 2001 · 106 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Identification of (3<i>R</i>)-7-Hydroxy-<i>N</i>-((1<i>S</i>)-1-{[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist

James B. Thomas, Robert N. Atkinson, N. Ariane Vinson et al. · Journal of Medicinal Chemistry · 2003 · 76 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans

James B. Thomas, Robert N. Atkinson, Nivedita Namdev et al. · Journal of Medicinal Chemistry · 2002 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

Brian F. Thomas, Ma. Elena Y. Francisco, Herbert H. Seltzman et al. · Bioorganic & Medicinal Chemistry · 2005 · 26 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists

James B. Thomas, Scott E. Fix, Richard B. Rothman et al. · Journal of Medicinal Chemistry · 2004 · 25 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17