George Ku

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

Keisuke Kuida, Judith A. Lippke, George Ku et al. · Science · 1995 · 1.6K citations

Life Sciences, Cell Biology, Immunology +16

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Yong Gu, Keisuke Kuida, Hiroko Tsutsui et al. · Science · 1997 · 1.2K citations

Veterinary Medicine, Immunology, Pathobiology +17

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

Woods Wannamaker, Robert M. D. Davies, Mark Namchuk et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 319 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

Giamila Fantuzzi, George Ku, Matthew W. Harding et al. · The Journal of Immunology · 1997 · 234 citations · Full text

Veterinary Medicine, Immunology, Pathology +17

Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy

Teresa Ravizza, Sian‐Marie Lucas, Silvia Balosso et al. · Epilepsia · 2006 · 173 citations · Full text

Life Sciences, Neuroscience, Pharmacology +12