Obesity is associated with hypothalamic injury in rodents and humans

Joshua P. Thaler, Chun‐Xia Yi, Ellen A. Schur, +16

Journal of Clinical Investigation

Hypothalamic InjuryReactive GliosisHigh-fat DietObesityMetabolic Syndrome +17

FGF19 action in the brain induces insulin-independent glucose lowering

Gregory J. Morton, Miles E. Matsen, Deanna P. Bracy, +6

Journal of Clinical Investigation

Human GrowthCaloric RestrictionGlucose ToleranceInsulin SignalingGastrointestinal Peptide Hormone +18

Functional identification of a neurocircuit regulating blood glucose

Thomas H. Meek, Jarrell T. Nelson, Miles E. Matsen, +11

Proceedings of the National Academy of Sciences

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

Jonathan P. German, Joshua P. Thaler, Brent E. Wisse, +7

Endocrinology

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, +9

Nature Communications

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

Jonathan P. German, Brent E. Wisse, Joshua P. Thaler, +9

Diabetes

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

Jarrad M. Scarlett, Jennifer M. Rojas, Miles E. Matsen, +11

Nature Medicine

InflammationRegenerative MedicineMetabolic SyndromeFibrosisDevelopmental Biology +9

The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling

Gregory J. Morton, James E. Blevins, Francis Kim, +2

American Journal of Physiology-Endocrinology and Metabolism

NutritionFood IntakeVentral Tegmental AreaGastrointestinal Peptide HormoneNutrient Signalling +21

BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production

Thomas H. Meek, Brent E. Wisse, Joshua P. Thaler, +6

Diabetes

Glucose UptakeInsulin SignalingMetabolic SyndromeHepatic Glucose ProductionDiabetic Neuropathy +19

Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus

Zaman Mirzadeh, Kimberly M. Alonge, Elaine Cabrales, +9

Nature Metabolism

Neural MechanismDevelopmental BiologyNeuronal MaturationHypothalamusNeuroanatomy +11