Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance

Yajuan Qi, Zihui Xu, Qinglei Zhu, +7

Diabetes

Heart FailurePathologyCell DeathInsulin ReceptorMetabolic Remodeling +20

Phosphorylation of Cardiac Myosin-Binding Protein-C Is a Critical Mediator of Diastolic Function

Paola C. Rosas, Yang Liu, Mohamed I. Abdalla, +14

Circulation Heart Failure

Activation of Foxo1 by Insulin Resistance Promotes Cardiac Dysfunction and β–Myosin Heavy Chain Gene Expression

Yajuan Qi, Qinglei Zhu, Kebin Zhang, +7

Circulation Heart Failure

Smooth Muscle Cell α ₂ δ-1 Subunits Are Essential for Vasoregulation by Ca _V 1.2 Channels

John P. Bannister, Adebowale Adebiyi, Guiling Zhao, +4

Circulation Research

Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system

Candice Thomas, Qian Yong, Rodolfo Mattar Rosa, +7

American Journal of Physiology-Heart and Circulatory Physiology

HypertensionImmunologyCardiovascular FunctionInsulin SignalingOxidative Stress +25

Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline

Sandeep Kumar, Chuanyu Wei, Candice Thomas, +6

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleHypertensionHeart FailureGeneticsPulmonary Hypertension +22

Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor

Candice Thomas, Qian Yong, Rachid Seqqat, +4

Clinical Science

Angiotensin Receptor AntagonistHypertensionHeart FailureDiabetic MiceCardiovascular Pharmacology +16

Do multiple nuclear factor kappa B activation mechanisms explain its varied effects in the heart?

Rajesh Kumar, Qian Yong, Candice Thomas

PubMed

Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice

Sen Zhu, Rakeshwar S. Guleria, Candice Thomas, +6

Journal of Molecular and Cellular Cardiology

Cardiac MuscleCardiovascular FunctionCardiovascular ToxicityOxidative StressMolecular Pharmacology +14

Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors

Qian Yong, Candice Thomas, Rachid Seqqat, +3

Cardiovascular Diabetology