CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

Cameron J. Turtle, Laïla-Aïcha Hanafi, Carolina Berger, +20

Journal of Clinical Investigation

Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 ⁺ and CD4 ⁺ CD19-specific chimeric antigen receptor–modified T cells

Cameron J. Turtle, Laïla‐Aïcha Hanafi, Carolina Berger, +13

Science Translational Medicine

ImmunologyPathologyCd4 T Cell ResponsesT CellsImmunotherapy +17

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

Daniel Sommermeyer, Michael Hudecek, Paula L. Kosasih, +4

Leukemia

Superior Antitumor ReactivityTumor ImmunologyCancer ImmunosurveillanceAutoimmune DiseaseMedicine +8

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Maik Luu, Zeno Riester, Adrian Baldrich, +23

Nature Communications

Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

Michael Hudecek, Maria Teresa Lupo Stanghellini, Paula L. Kosasih, +4

Clinical Cancer Research

The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for <i>In Vivo</i> Antitumor Activity

Michael Hudecek, Daniel Sommermeyer, Paula L. Kosasih, +5

Cancer Immunology Research

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

Katrin Mestermann, Theodoros Giavridis, Justus Weber, +7

Science Translational Medicine

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)

Patrick Hayden, Claire Roddie, Peter Bader, +33

Annals of Oncology

Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Ibrahim Yakoub‐Agha, Christian Chabannon, Peter Bader, +23

Haematologica

Cell TherapyImmunologyTransplantation MedicineCell Replacement TherapyImmunotherapeutics +22

Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma

Matteo Da Vià, Oliver Dietrich, Marietta Truger, +24

Nature Medicine

Hematological MalignancyAutoimmune DiseaseMalignant Blood DisorderHematologyImmunology +6