Theodore R. Holman

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel, Yulia Y. Tyurina, Jinming Zhao et al. · Cell · 2017 · 920 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +9

N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E ₂ to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

Saravanan S. Karuppagounder, Lauren Alin, Yingxin Chen et al. · Annals of Neurology · 2018 · 294 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Haider H. Dar, Yulia Y. Tyurina, Karolina Mikulska‐Ruminska et al. · Journal of Clinical Investigation · 2018 · 241 citations · Full text

Life Sciences, Cell Biology, Microbiology +13

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

Joshua D. Deschamps, Victor Kenyon, Theodore R. Holman · Bioorganic & Medicinal Chemistry · 2006 · 164 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +5

Purification and characterization of VanR and the cytosolic domain of VanS: A two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147

Gerard D. Wright, Theodore R. Holman, Christopher T. Walsh · Biochemistry · 1993 · 143 citations · Full text

Life Sciences, Microbiology, Molecular Biology +13