Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Gang Chen, Alexander C. Huang, Wei Zhang, +36

Nature

Exosomal Pd-l1 ContributesAllergyAutoimmune DiseaseAnti-pd-1 ResponseImmune Regulation +9

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

Zebin Xiao, Leslie Todd, Li Huang, +14

Nature Communications

PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Hezhe Lu, Shujing Liu, Gao Zhang, +38

Nature

Braf-mutant MelanomasTumor BiologyHealth SciencesMedicineReceptor Tyrosine Kinase +8

ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

Wei Zhang, Wenqun Zhong, Beike Wang, +17

Developmental Cell

Icam-1-mediated AdhesionSignal TransductionCell AdhesionCell TraffickingImmunology +9

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma

Lu Gao, Wei Zhang, Wenqun Zhong, +4

Oncology Reports

ImmunologyBiological MicroenvironmentsPathologyCancer BiologyTumor Biology +17

Near‐Infrared Fluorescent Ag₂Se–Cetuximab Nanoprobes for Targeted Imaging and Therapy of Cancer

Chunnan Zhu, Gang Chen, Zhi‐Quan Tian, +5

Small

Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

Kamila Butowska, Xuexiang Han, Ningqiang Gong, +7

Acta Pharmaceutica Sinica B

Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

Wenqun Zhong, Youtao Lu, Xuexiang Han, +22

Cell Reports

Oncogenic BRAF-Mediated Melanoma Cell Invasion

Hezhe Lu, Shujing Liu, Gao Zhang, +18

Cell Reports

Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors

Wenqun Zhong, Zebin Xiao, Zhiyuan Qin, +11

Cancer Research