N L McIntosh

Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin.

D E Lopes de Menezes, Norma J. Hudon, N L McIntosh et al. · PubMed · 2000 · 93 citations

Medicine, Oncology, Pharmacology +17

Role of Drug Release and Liposome-Mediated Drug Delivery in Governing the Therapeutic Activity of Liposomal Mitoxantrone Used to Treat Human A431 and LS180 Solid Tumors

Howard J. Lim, Dana Masin, N L McIntosh et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 60 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Doxorubicin encapsulated in sterically stabilized liposomes exhibits renal and biliary clearance properties that are independent of valspodar (PSC 833) under conditions that significantly inhibit nonencapsulated drug excretion.

Rajesh Krishna, N L McIntosh, K. Wayne Riggs et al. · PubMed · 1999 · 32 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Kupffer cells do not play a role in governing the efficacy of liposomal mitoxantrone used to treat a tumor model designed to assess drug delivery to liver.

Howard J. Lim, Michael Parr, Dana Masin et al. · PubMed · 2000 · 15 citations

Pharmacy, Pharmaceutics, Pharmacology +17