Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

Adam Gołȩbiowski, Darren L. Whitehouse, R. Paul Beckett, +16

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityBiochemistryMedicineUgi ReactionNatural Sciences +6

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, +17

Journal of Medicinal Chemistry

Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis

Piotr Sklepkiewicz, Barbara Dymek, Michał Mlącki, +19

European Journal of Pharmacology

Discovery of <b>OATD-01</b>, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Robert Koralewski, Barbara Dymek, Marzena Mazur, +29

Journal of Medicinal Chemistry

Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases

Marzena Mazur, Barbara Dymek, Robert Koralewski, +19

Journal of Medicinal Chemistry

Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1

Wojciech Czestkowski, Łukasz Krzemiński, Michał Piotrowicz, +25

Journal of Medicinal Chemistry

Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma

Piotr Sklepkiewicz, Barbara Dymek, Michał Mlącki, +11

International Journal of Molecular Sciences

AsthmaInflammatory Lung DiseaseLung InflammationImmunologySevere Asthma +16

Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral administration

Jakub Fichna, Marzena Mazur, Daria Grzywacz, +9

Bioorganic & Medicinal Chemistry Letters

Peripheral AdministrationHealth SciencesPain MedicineMedicinePhysiology +11

Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2

Renata Perlikowska, Justyna Piekielna‐Ciesielska, Marzena Mazur, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryEndomorphin-2 AnalogsPain MedicinePosition 2Medicine +10

Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

Gleb Andryianau, Michał Kowalski, Michał Piotrowicz, +20

ACS Medicinal Chemistry Letters