Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

Victoria Hung, Peng Zou, Hyun‐Woo Rhee, +6

Molecular Cell

Ratiometric Apex TaggingLive CellsMitochondrial FunctionProtein FoldingMedicine +9

Complementation of mitochondrial electron transport chain by manipulation of the NAD ⁺ /NADH ratio

Denis V. Titov, Valentin Cracan, Russell P. Goodman, +3

Science

Molecular BiologyMitochondrial BiologyMitochondrial NadRedox BiologyOxidative Stress +14

IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins

Ning Dai, Liping Zhao, Diedra M. Wrighting, +11

Cell Metabolism

ObesityMetabolic SyndromeInsulin SignalingHealth SciencesMitochondrial Function +11

A genetically encoded tool for manipulation of NADP+/NADPH in living cells

Valentin Cracan, Denis V. Titov, Hongying Shen, +2

Nature Chemical Biology

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

Vishal M. Gohil, Lin Zhu, Charli D. Baker, +7

Journal of Biological Chemistry

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Andrey A. Parkhitko, Divya Ramesh, Lin Wang, +9

eLife

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

Xingxiu Pan, Mina Heacock, Evana N. Abdulaziz, +7

Nature Chemical Biology

Reductive StressCellular EnzymologyMedicineCellular Nadh/nad+ RatioNatural Sciences +8

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits

Charandeep Singh, Byungchang Jin, Nirajan Shrestha, +19

Cell Metabolism

Reductive StressTranscriptional RegulationSystems BiologySignal TransductionMolecular Regulation +8

IcmF Is a Fusion between the Radical B12 Enzyme Isobutyryl-CoA Mutase and Its G-protein Chaperone

Valentin Cracan, Dominique Padovani, Ruma Banerjee

Journal of Biological Chemistry

Aldo-keto ReductaseCellular EnzymologyBiochemistryActive IcmIcm Activity +13

Visualization of a radical B ₁₂ enzyme with its G-protein chaperone

Marco Jost, Valentin Cracan, Paul A. Hubbard, +2

Proceedings of the National Academy of Sciences