Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Roeben N. Munji, Allison Soung, Geoffrey Weiner, +14

Nature Neuroscience

Endothelial Cell PathobiologyDisease ModelsNeurodegenerative DiseasesBlood–brain BarrierEndothelial Dysfunction +10

Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm

Fumiaki Shikata, Kenji Shimada, Hiroki Sato, +11

Hypertension

DysbiosisAneurysm FormationImmunologyGut MicrobiotaGut Microbiota Depletion +17

Protective Role of Peroxisome Proliferator–Activated Receptor-γ in the Development of Intracranial Aneurysm Rupture

Kenji Shimada, Hajime Furukawa, Kosuke Wada, +9

Stroke

Roles of Nicotine in the Development of Intracranial Aneurysm Rupture

Yoshinobu Kamio, Takeshi Miyamoto, Tetsuro Kimura, +9

Stroke

Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture

Masaaki Korai, James W. Purcell, Yoshinobu Kamio, +10

Hypertension

Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model

Takeshi Miyamoto, David Kung, Keiko T. Kitazato, +10

Journal of Cerebral Blood Flow & Metabolism

ImmunologyWillis CircleCerebral Vascular RegulationNeuroinflammationInflammation +17

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats

Masaaki Korai, Keiko T. Kitazato, Yoshiteru Tada, +7

Journal of Neuroinflammation

Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats

Hidetsugu Maekawa, Yoshiteru Tada, Kenji Yagi, +6

Journal of Neuroinflammation

Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury

Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, +7

Stroke

Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats

Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, +8

Journal of neurosurgery