The Crystal Structure of Human Argonaute2

N.T. Schirle, Ian J. MacRae

Science

X-ray CrystallographyHuman Argonaute2Tandem Tryptophan-binding PocketsCrystal StructureBiochemistry +13

Structural basis for microRNA targeting

N.T. Schirle, Jessica Sheu‐Gruttadauria, Ian J. MacRae

Science

BioinformaticsNatural SciencesGeneticsRna BiologyMolecular Biology +10

A Dynamic Search Process Underlies MicroRNA Targeting

Stanley D. Chandradoss, N.T. Schirle, Malwina Szczepaniak, +2

Cell

Functional GenomicsGeneticsMicrorna DetectionSmall RnaGene Expression +3

RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1

Jongchan Yeo, Rena A. Goodman, N.T. Schirle, +2

Proceedings of the National Academy of Sciences

In Vivo Gene TherapyGeneticsMolecular BiologyPreferred Editing SiteTranscriptional Regulation +15

Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets

N.T. Schirle, Jessica Sheu‐Gruttadauria, Stanley D. Chandradoss, +2

eLife

Human Argonaute2Transcriptional RegulationDirect Post-transcriptional RegulationSignal TransductionNatural Sciences +11

Helix‐7 in Argonaute2 shapes the microRNA seed region for rapid target recognition

Shannon Klum, Stanley D. Chandradoss, N.T. Schirle, +2

The EMBO Journal

BioinformaticsRapid Target RecognitionMicrorna Seed RegionNatural SciencesMolecular Biology +7

Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide

N.T. Schirle, Garth A. Kinberger, Heather F. Murray, +3

Journal of the American Chemical Society

Crystal StructureHuman Argonaute-2 BoundStable SirnaEngineeringModified Sirna Guide +13

Structure-Guided Control of siRNA Off-Target Effects

Scott R. Suter, Jessica Sheu‐Gruttadauria, N.T. Schirle, +5

Journal of the American Chemical Society

Rna ProcessingSystems BiologyEngineeringRna Structure PredictionRna Biology +11

Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide

N.T. Schirle, Rena A. Goodman, Malathy Krishnamurthy, +1

Organic & Biomolecular Chemistry

Molecular BiologyReceptor Pre-mrnaSerotonin 2CAntisense TherapyOff-target Effect +16

Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay

Malathy Krishnamurthy, N.T. Schirle, Peter A. Beal

Bioorganic & Medicinal Chemistry

Helix-threading PeptidesBiochemistryProtein FoldingNatural SciencesMedicine +7