Cell-programmed nutrient partitioning in the tumour microenvironment

Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf, +29

Nature

MedicineBiological MicroenvironmentsCell ProliferationCancer BiologyCell Biology +4

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Marc O. Johnson, Melissa M. Wolf, Matthew Z. Madden, +20

Cell

Reductive StressCellular EnzymologyBiochemistryMolecular RegulationGlutaminase-dependent Metabolism +8

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

Kyung‐min Lee, Jennifer M. Giltnane, Justin M. Balko, +16

Cell Metabolism

Tumor BiologyBreast OncologyMitochondrial FunctionMedicineMitochondrial Oxidative Phosphorylation +6

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, +21

Immunity

Signal TransductionSignaling PathwayCell RegulationImmunologyMetabolic Checkpoint +5

Obesity induces PD-1 on macrophages to suppress anti-tumour immunity

Jackie E. Bader, Melissa M. Wolf, Gian Luca Lupica-Tondo, +30

Nature

InflammationCancer ImmunosurveillanceImmunologyTumor ImmunityAutophagy +6

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy

Lihong Wang-Bishop, Blaise R. Kimmel, Verra M. Ngwa, +23

Science Immunology

NanoparticlesEngineeringImmunologyImmunoeditingImmunotherapy +15

Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

Anna E. Vilgelm, Kensey Bergdorf, Melissa M. Wolf, +20

iScience

MedicineTumor TargetingOrganoid ModelsCancer TreatmentOncology +4

Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response

Shilpak Chatterjee, Paramita Chakraborty, Anusara Daenthanasanmak, +13

Clinical Cancer Research

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, +15

Cellular and Molecular Gastroenterology and Hepatology

Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation

Nowrin U. Chowdhury, Jacqueline-Yvonne Cephus, Emely Henriquez Pilier, +21

Journal of Clinical Investigation