Michael A Hagler

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Carolyn M Roos, Bin Zhang, Allyson K. Palmer et al. · Aging Cell · 2016 · 723 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

Michael A Hagler, Thomas M. Hadley, Heyu Zhang et al. · Cardiovascular Research · 2013 · 139 citations · Full text

Life Sciences, Cardiology, Molecular Biology +17

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease

Nassir M Thalji, Michael A Hagler, Heyu Zhang et al. · Circulation Cardiovascular Genetics · 2015 · 62 citations · Full text

Life Sciences, Cardiology, Molecular Biology +12

Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice

Carolyn M Roos, Michael A Hagler, Bin Zhang et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2013 · 51 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy

Bin Zhang, Maurice Enriquez‐Sarano, Hartzell V. Schaff et al. · Circulation · 2025 · 21 citations

Medicine, Cardiology, Pharmacology +15