Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens, Chris Greenman, Beiyuan Fu, +29

Cell

A comprehensive catalogue of somatic mutations from a human cancer genome

Erin Pleasance, R. Keira Cheetham, Philip J. Stephens, +42

Nature

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Gillian L. Dalgliesh, Kyle Furge, Chris Greenman, +48

Nature

ChromatinCancer ResearchUrologyHistone Modifying GenesGenitourinary Cancer +9

A small-cell lung cancer genome with complex signatures of tobacco exposure

Erin Pleasance, Philip J. Stephens, Sarah O’Meara, +37

Nature

Complex landscapes of somatic rearrangement in human breast cancer genomes

Philip J. Stephens, David J. McBride, Meng‐Lay Lin, +30

Nature

ChromatinComplex LandscapesSomatic VariantTumor HeterogeneityNatural Sciences +9

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Gijs van Haaften, Gillian L. Dalgliesh, Helen Davies, +59

Nature Genetics

Histone ModificationsChromatinSomatic VariantSomatic MutationsChromatin Remodeling +9

Involvement of kinesin family member 2C/mitotic centromere‐associated kinesin overexpression in mammary carcinogenesis

Arata Shimo, Chizu Tanikawa, Toshihiko Nishidate, +9

Cancer Science

Single-cell paired-end genome sequencing reveals structural variation per cell cycle

Thierry Voet, Parveen Kumar, Peter Van Loo, +20

Nucleic Acids Research

GeneticsMolecular GeneticsCell CycleGenomicsHigh Throughput Sequencing +17

Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer

Jungwon Kim, Miki Akiyama, Jae‐Hyun Park, +8

Cancer Science

Systems BiologySignal TransductionBreast OncologySignaling PathwayHormonal Receptor +12

LRH-1 drives colon cancer cell growth by repressing the expression of the<i>CDKN1A</i>gene in a p53-dependent manner

Holly B Kramer, Chun‐Fui Lai, Hetal Patel, +7

Nucleic Acids Research

Tumor BiologySignaling PathwayCell RegulationP53 DependenceP53-dependent Manner +13