Douglas F. Covey

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Brian M. Castellano, Ashley Thelen, Ofer Moldavski et al. · Science · 2017 · 544 citations · Full text

Proteinlipid Interaction, Molecular Biology, Rapamycin Complex 1 +18

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

Mathieu Blanc, Wei Yuan Hsieh, Kevin A. Robertson et al. · Immunity · 2012 · 393 citations · Full text

Inflammation, Cytokine, Viral Replication +7

Structural basis of Smoothened regulation by its extracellular domains

Eamon F.X. Byrne, Ria Sircar, Paul S. Miller et al. · Nature · 2016 · 358 citations · Full text

Signal Transduction, Molecular Physiology, Molecular Regulation +10

Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.

Ren-Qi Huang, Cathy L. Bell-Horner, Mohammed Dibas et al. · PubMed · 2001 · 337 citations

Other Ptx-site Ligands, Pentylenetetrazole-induced Inhibition, Pharmacotherapy +20

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

Xiaochao Wei, Haowei Song, Li Yin et al. · Nature · 2016 · 310 citations · Full text

Inflammation, Metabolic Syndrome, Engineering +9