John J. Alvarado

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

Lori A. Emert‐Sedlak, Purushottam Narute, Sherry T. Shu et al. · Chemistry & Biology · 2013 · 52 citations · Full text

Signal Transduction, Antiretroviral Activity, Medicine +10

Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein

Robert Lodge, Lélia Delamarre, Jean-Philippe Lalonde et al. · Journal of Virology · 1997 · 45 citations · Full text

Distinct Oncornaviruses, Immunology, Molecular Biology +17

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

John J. Alvarado, Sreya Tarafdar, Joanne I. Yeh et al. · Journal of Biological Chemistry · 2014 · 42 citations · Full text

Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

John J. Alvarado, Laurie Betts, Jamie A. Moroco et al. · Journal of Biological Chemistry · 2010 · 34 citations · Full text

Src Homology, Crystal Structure, Protein Function +15

Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470

John J. Alvarado, Anjana Nemkal, J.M. Sauder et al. · Molecular and Biochemical Parasitology · 2009 · 33 citations · Full text

Biosynthesis, Biochemistry, Biomolecular Structure Prediction +4