s with an ultrasmall diameter of about 2.3 nm and an ultrahigh density of about 4 × 10¹² cm^-2. Light reflected from parallel interfaces of the MSNM gives rise to the interferometric pattern with constructive and destructive fringes. The adsorption of VOCs to a highly porous MSNM varies the refractive index of the MSNM, resulting in the shift of the reflectometric interference spectrum (RIS) and thus yielding highly sensitive responses with a limit of detection (LOD) at the ppb level. Moreover, the sensor selectively responds to polar ethanol and acetone, as well as aromatic benzene, toluene, and chlorobenzene, but is insensitive to nonpolar ethane or hexane. The selectivity most likely arises from hydrogen bonding and dipole interaction of VOCs with silica surface.22:T470,Nonvolatile buffers and inorganic salts used for isolation and stabilization of biological samples are essential to be cleaned up prior to mass spectrometry (MS) analysis because of their deleterious effects such as ion suppression and instrumental pollution. In this work, a centimeter-scale continuous silica isoporous membrane (SIM) was prepared and integrated into a facile microfluidic chip for the desalting of protein samples based on dialysis principle. Thanks to the uniform pore size (∼2.3 nm in diameter), ultrasmall thickness (90 nm) and high pore density (4.0 × 10¹² pores cm^-2, corresponding to a porosity of 16.7%) of SIM, the device achieved ∼99% desalting efficiency for the sample with 154 mM NaCl (isotonic saline) at a flow rate of 1 μL min^-1, while protein loss was only 5%. High-quality electrospray ionization (ESI)-MS spectra of cytochrome c dissolved in isotonic saline was obtained after the desalting treatment. In addition, the SIM-based microfluidic device was successfully online-coupled with microchip ESI-MS for real-time desalting and characterization of proteins.23:T5bb,

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