A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

Michelle Maurer, Mark S. Gresnigt, Antonia Last, +15

Biomaterials

Microbial Interaction StudiesVitro PlatformImmunologyOrgan-on-a-chipMicrobiology +8

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Helmut Pein, Alexia Ville, Simona Pace, +28

Nature Communications

Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions

Martin Raasch, Knut Rennert, Tobias Jahn, +8

Biofabrication

Tissue EngineeringBiochip DesignEngineeringEndothelial CellsCell Adhesion +20

Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery

Christoph Englert, Anne‐Kristin Trützschler, Martin Raasch, +5

Journal of Controlled Release

Polymer-drug ConjugateMedicineNeuroprotectionGene DeliveryBiomedical Engineering +2

Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase

Lea Thomas, Zhigang Rao, Jana Gerstmeier, +8

Biochemical Pharmacology

Macrophage BiologyInflammationCytokineTnfα ExpressionImmune Cell Development +13

Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo

Alexandra C. Rinkenauer, Adrian T. Press, Martin Raasch, +8

Journal of Controlled Release

NanoparticlesNanomedicineTissue EngineeringEngineeringMethacrylate-based Nanoparticles +5

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

Carlo Pergola, Katrin Schubert, Simona Pace, +13

Scientific Reports

An integrative microfluidically supported <i>in vitro</i> model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development

Martin Raasch, Knut Rennert, Tobias Jahn, +5

Biomicrofluidics

Immune RegulationImmunologyBiomedical EngineeringGliomaCerebral Vascular Regulation +29

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model

Tim Kaden, Katja Graf, Knut Rennert, +3

Scientific Reports

ImmunotoxicologyImmunologyPathologyPharmacotherapyInflammation +17

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

Konstantin Neukirch, Khaled Alsabil, Chau Phi Dinh, +29

Journal of Medicinal Chemistry