Armen O. Simonyan

Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle

Yurii S. Borovikov, Stanislava V. Avrova, Nikita A. Rysev et al. · Archives of Biochemistry and Biophysics · 2015 · 19 citations

Mechanobiology, Physiology, Aberrant Movement +6

Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle

Olga E. Karpicheva, Armen O. Simonyan, Nadezhda Kuleva et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2015 · 17 citations

Strong-binding Cross-bridges, Signal Transduction, Natural Sciences +9

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies

Yurii S. Borovikov, Olga E. Karpicheva, Armen O. Simonyan et al. · International Journal of Molecular Sciences · 2018 · 17 citations · Full text

Deviations in conformational rearrangements of thin filaments and myosin caused by the Ala155Thr substitution in hydrophobic core of tropomyosin

Olga E. Karpicheva, Vladimir V. Sirenko, Nikita A. Rysev et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2017 · 14 citations

Hydrophobic Core, Thin Filaments, Protein Assembly +11

The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle

Yurii S. Borovikov, Armen O. Simonyan, Olga E. Karpicheva et al. · Biochemical and Biophysical Research Communications · 2017 · 12 citations

Signal Transduction, Molecular Physiology, Cellular Enzymology +12