Amplification of EGFR Wild-Type Alleles in Non–Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors

Shigenari Nukaga, Hiroyuki Yasuda, Katsuya Tsuchihara, +10

Cancer Research

<i>In vitro</i> modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant <i>EGFR</i> mutants in non-small-cell lung cancer

Toshiyuki Hirano, Hiroyuki Yasuda, Tetsuo Tani, +12

Oncotarget

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

Hideo Watanabe, Kenzo Soejima, Hiroyuki Yasuda, +5

Cancer Cell International

Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial

Masaharu Shinkai, Kenji Tsushima, Shingo Tanaka, +36

Infectious Diseases and Therapy

Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer

Masayoshi Miyawaki, Hiroyuki Yasuda, Tetsuo Tani, +11

Molecular Cancer Research

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

Toshiki Ebisudani, Junko Hamamoto, Kazuhiro Togasaki, +25

Cell Reports

Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in <i>ALK</i> -Translocated Lung Cancer Cells

Tetsuo Tani, Hiroyuki Yasuda, Junko Hamamoto, +10

Molecular Cancer Therapeutics

Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer

Ichiro Kawada, Rifat Hasina, Qudsia Arif, +5

Cancer Research

Tumor BiologyMedicineDramatic Antitumor EffectsTumor GrowthPharmacology +13

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Keita Masuzawa, Hiroyuki Yasuda, Junko Hamamoto, +6

Oncotarget

MET and PI3K/mTOR as a Potential Combinatorial Therapeutic Target in Malignant Pleural Mesothelioma

Rajani Kanteti, Immanuel Dhanasingh, Ichiro Kawada, +9

PLoS ONE

Mpm XenograftsMalignant Pleural MesotheliomaGliomaMalignant DiseaseMedicine +13