Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

Eleni P. Mimitou, Caleb A. Lareau, Kelvin Y. Chen, +18

Nature Biotechnology

BioinformaticsChromatinChromatin AccessibilityChromatin RemodelingSingle Cell Sequencing +12

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases

Mineto Ota, Yasuo Nagafuchi, Hiroaki Hatano, +38

Cell

InflammationImmunogeneticsAutoimmune DiseaseAdaptive Immune SystemImmune Cell Development +13

Distinct transcriptome architectures underlying lupus establishment and exacerbation

M Nakano, Mineto Ota, Yusuke Takeshima, +27

Cell

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, +19

Nature Communications

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, +14

Nature Genetics

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, +20

JCI Insight

Trained ImmunityAdaptive Immune SystemInnate Immune SystemImmunologyImmune Regulation +18

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, +16

Cell Genomics

Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus

Yusuke Takeshima, Yukiko Iwasaki, M Nakano, +11

Annals of the Rheumatic Diseases

Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis

Satomi Kobayashi, Yasuo Nagafuchi, Mai Okubo, +13

Journal of Autoimmunity

EngineeringImmunologyMultiomicsTranscriptomics TechnologyInflammation +16

Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance

Saeko Yamada, Yasuo Nagafuchi, Min Wang, +24

Annals of the Rheumatic Diseases