Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

Chiara Francavilla, Kristoffer Rigbolt, Kristina B. Emdal, +10

Molecular Cell

Signal TransductionSignaling PathwayMedicineNatural SciencesReceptor Tyrosine Kinase +8

Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

Aurélien Dugourd, Christoph Kuppe, Marco Sciacovelli, +15

Molecular Systems Biology

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, +13

Cell

Signal TransductionSignaling PathwayNatural SciencesGeneticsProtein Recruitment +7

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation

Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker‐Jensen, +8

Science Signaling

E3 Ligase Cbl-bNeuroblastoma Cell DifferentiationGliomaNeuroblastoma CellsNgf Stimulation +15

Dynamic lineage priming is driven via direct enhancer regulation by ERK

William B. Hamilton, Yaron Mosesson, Rita S. Monteiro, +6

Nature

Transcriptional RegulationCell LineageDevelopmental BiologyDynamic Lineage PrimingMedicine +8

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, +25

Nature Communications

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Hui Liu, Charles J. Murphy, Florian A. Karreth, +6

Cancer Discovery

NFκB signaling is important for growth of antiestrogen resistant breast cancer cells

Christina W. Yde, Kristina B. Emdal, Bárbara Guerra, +1

Breast Cancer Research and Treatment

Breast OncologyMedicineCancer GrowthNfκb SignalingBreast Cancer +7

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker‐Jensen, +6

Science Signaling

Cell DeathInsulin ReceptorGliomaNeuroblastoma CellsTumor Biology +15

Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles

Anders Kverneland, Ole Østergaard, Kristina B. Emdal, +2

PROTEOMICS

Extracellular MicrovesiclesAnalytical UltracentrifugationProteomic TechnologyBioanalysisPlasma Proteomics +19