Haoxing Yuan

Benzodiazepine Derivatives as Potent Vasopressin V₂ Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease

Xudong Cao, Peng Wang, Haoxing Yuan et al. · Journal of Medicinal Chemistry · 2022 · 29 citations · Full text

Long Residence Time at the Vasopressin V₂ Receptor Translates into Superior Inhibitory Effects in <i>Ex Vivo</i> and <i>In Vivo</i> Models of Autosomal Dominant Polycystic Kidney Disease

Haoran Zhang, Wenzhong Yan, Yongzhan Sun et al. · Journal of Medicinal Chemistry · 2022 · 26 citations · Full text

Structure–Affinity and Structure–Kinetic Relationship Studies of Benzodiazepine Derivatives for the Development of Efficacious Vasopressin V₂ Receptor Antagonists

Xudong Cao, Peng Wang, Wenchao Zhao et al. · Journal of Medicinal Chemistry · 2023 · 15 citations

<scp>PF</scp>‐06409577 inhibits renal cyst progression by concurrently inhibiting the <scp>mTOR</scp> pathway and <scp>CFTR</scp> channel activity

Limin Su, Haoxing Yuan, Haoran Zhang et al. · FEBS Open Bio · 2022 · 11 citations · Full text

Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V₂ Receptor in <i>In Vitro</i>, Ex Vivo, and In Vivo Models of ADPKD

Xiaoke Gu, Haoxing Yuan, Wenchao Zhao et al. · Journal of Medicinal Chemistry · 2022 · 10 citations · Full text