Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

Danny Jonigk, Mariam Al-Omari, Lavinia Maegel, +15

Proceedings of the National Academy of Sciences

α-1 Antitrypsin Promotes Semimature, IL-10–Producing and Readily Migrating Tolerogenic Dendritic Cells

Eyal Ozeri, Mark Mizrahi, Galit Shahaf, +1

The Journal of Immunology

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +25

α-1-Antitrypsin Gene Delivery Reduces Inflammation, Increases T-Regulatory Cell Population Size and Prevents Islet Allograft Rejection

Galit Shahaf, Hadas Moser, Eyal Ozeri, +3

Molecular Medicine

ImmunodeficienciesT-regulatory CellImmunologyImmune RegulationImmunodominance +24

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice

Sandhya Subramanian, Galit Shahaf, Eyal Ozeri, +4

Metabolic Brain Disease

InflammationAutoimmune DiseaseImmunologyImmune RegulationPathology +10

Acute Phase Protein α1-Antitrypsin Reduces the Bacterial Burden in Mice by Selective Modulation of Innate Cell Responses

Ziv Kaner, David E. Ochayon, Galit Shahaf, +4

The Journal of Infectious Diseases

PKCη enhances cell cycle progression, the expression of G1 cyclins and p21 in MCF-7 cells

Eyal Fima, Marat Shtutman, Pazit Libros, +4

Oncogene

Cell RegulationCell DivisionMolecular PathwayCell SignalingMcf-7 Cells +8

PKCη is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation:

Adva Maissel, Mairav Marom, Marat Shtutman, +2

Cellular Signalling

Signal TransductionCell SignalingNatural SciencesMolecular BiologyNuclear Envelope +8

α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation

Avishag Abecassis, Ronen Schuster, Galit Shahaf, +5

Cellular and Molecular Immunology

InflammationIslet TransplantationTransplantationMedicinePancreatic Islet Biology +11

Revascularization of Pancreatic Islet Allografts is Enhanced by α-1-Antitrypsin under Anti-Inflammatory Conditions

Keren Bellacen, Noa Kalay, Eyal Ozeri, +2

Cell Transplantation

ImmunologyPancreas TransplantationInflammationAngiogenesisAnti-inflammatory Conditions +20

Pancreatic Islet Xenograft Survival in Mice Is Extended by a Combination of Alpha-1-Antitrypsin and Single-Dose Anti-CD4/CD8 Therapy

Efrat Ashkenazi, Boris M. Baranovski, Galit Shahaf, +1

PLoS ONE