A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery

Martina Röhm, Stefan Carle, Frank Maigler, +5

International Journal of Pharmaceutics

EngineeringImmunologyPulmonary Drug DeliveryProtein NanoparticlesNanomedicine +19

An in-depth examination of fatty acid solubility limits in biotherapeutic protein formulations containing polysorbate 20 and polysorbate 80

Nils Glücklich, Mridula Dwivedi, Stefan Carle, +3

International Journal of Pharmaceutics

Food ColloidLipid AnalysisBiochemistryIn-depth ExaminationPolysorbate 20 +3

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Manuel Schuster, Leonie Schnell, Peter Feigl, +14

Scientific Reports

Nose-to-Brain delivery of insulin for Alzheimer’s disease

Martina Stützle, J Flamm, Stefan Carle, +1

ADMET & DMPK

Synaptic TransmissionNose-to-brain DeliverySynaptic SignalingInsulin SignalingSocial Sciences +18

Assessing the polysorbate degradation fingerprints and kinetics of lipases – how the activity of polysorbate degrading hydrolases is influenced by the assay and assay conditions

Nils Glücklich, Stefan Carle, Julia Buske, +2

European Journal of Pharmaceutical Sciences

Lipid AnalysisPolysorbate Degradation FingerprintsEngineeringBiochemistryBioanalysis +7

Regulation of endo‐lysosomal pathway and autophagic flux by broad‐spectrum antipathogen inhibitor ABMA

Yu Wu, Claire Boulogne, Stefan Carle, +6

FEBS Journal

Endo‐lysosomal PathwayToxinologyAutophagic FluxNumerous ToxinsImmunology +15

Hydrolytic polysorbate 20 degradation – Sensitive detection of free fatty acids in biopharmaceuticals via UPLC-QDa analytics with isolator column

Dirk-H. Evers, Stefan Carle, Dániel Lakatos, +3

Journal of Chromatography B

Lipid AnalysisEngineeringBiochemistryBioanalysisFree Fatty Acids +10

Existence of a superior polysorbate fraction in respect to protein stabilization and particle formation?

Tim Diederichs, Judith J. Mittag, James Harry Humphrey, +4

International Journal of Pharmaceutics

Particle FormationProtein ChemistryProtein FoldingMedicineMolecular Biology +2

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

Stefan Carle, Marco Pirazzini, Ornella Rossetto, +2

Toxins