Sabine Aschenbrenner

Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

Felix Bubeck, Mareike D. Hoffmann, Zander Harteveld et al. · Nature Methods · 2018 · 208 citations · Full text

Engineering, Synthetic Biology, Molecular Biology +7

Cell-specific CRISPR–Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

Mareike D. Hoffmann, Sabine Aschenbrenner, Kleopatra Rapti et al. · Nucleic Acids Research · 2019 · 113 citations · Full text

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis

J. Beaudouin, Clarissa Liesche, Sabine Aschenbrenner et al. · Cell Death and Differentiation · 2013 · 72 citations · Full text

Inflammation, Cd95-induced Apoptosis, Signal Transduction +12

Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity

Sabine Aschenbrenner, Stefan M. Kallenberger, Mareike D. Hoffmann et al. · Science Advances · 2020 · 66 citations · Full text

Off-target Effect, Engineering, Specific Genome Editing +13

Optogenetic control of <i>Neisseria meningitidis</i> Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Mareike D. Hoffmann, Jan Mathony, Julius Upmeier zu Belzen et al. · Nucleic Acids Research · 2020 · 43 citations · Full text

Nmecas9 Activity, Engineering, Molecular Biology +18