The target landscape of clinical kinase drugs

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Science

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Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Alexey Stukalov, Virginie Girault, Vincent Grass, +27

Nature

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Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

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Nature Communications

ProteomicsDB: a multi-omics and multi-organism resource for life science research

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Nucleic Acids Research

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

Philipp Le, Elena Kunold, Robert Macsics, +18

Nature Chemistry

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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Jana Zecha, Florian Bayer, Svenja Wiechmann, +33

Science

Drug TargetChemoprevention StrategyKinase InhibitorsMolecular BiologyDrug-regulated Ptms +20

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Maria Reinecke, P. Brear, Larsen Vornholz, +12

Nature Chemical Biology

Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors

Maria Reinecke, Benjamin Ruprecht, Sandra Poser, +5

ACS Chemical Biology

Medicinal ChemistryPi3k Inhibitor ActionSignal TransductionDrug TargetSignaling Pathway +12

Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells

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Molecular Cancer Research

Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity

Václav Němec, Prashant Khirsariya, Pavlína Janovská, +12

Angewandte Chemie International Edition