Laura C. Bott

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

Emilie Tresse, Florian A. Salomons, Jouni Vesa et al. · Autophagy · 2010 · 436 citations · Full text

A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation

Anne Beskow, Kristian Björk Grimberg, Laura C. Bott et al. · Journal of Molecular Biology · 2009 · 117 citations

Proteasomal Degradation, Protein Function, Cellular Enzymology +14

Mutation in<i>CPT1C</i>Associated With Pure Autosomal Dominant Spastic Paraplegia

Carlo Rinaldi, Thomas Schmidt, Alan J. Situ et al. · JAMA Neurology · 2015 · 74 citations · Full text

A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy

Laura C. Bott, Nisha M. Badders, Ke‐lian Chen et al. · Human Molecular Genetics · 2016 · 74 citations · Full text

Drosophila Nrf1, Molecular Biology, Nrf2 Activator Mitigates +19

Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Carlo Rinaldi, Laura C. Bott, Ke‐lian Chen et al. · Molecular Medicine · 2012 · 62 citations · Full text