Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Marissa J. Schafer, Thomas A. White, Glenda L. Evans, +14

Diabetes

Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice

Laura Evgin, Tim Kottke, Jason M. Tonne, +18

Science Translational Medicine

Oncolytic virus-derived type I interferon restricts CAR T cell therapy

Laura Evgin, Amanda L. Huff, Phonphimon Wongthida, +17

Nature Communications

Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny

Tayaramma Thatava, Timothy J. Nelson, Ramakrishna Edukulla, +7

Gene Therapy

Human Ips CellsDevelopmental BiologyGlucose-responsive Insulin-secreting ProgenyDiabetesMetabolic Regulation +8

Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats

Alessandro Cataliotti, Jason M. Tonne, Diego Bellavia, +9

Circulation

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Christopher B. Driscoll, Matthew Schuelke, Timothy Kottke, +17

Nature Communications

B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival

Sara J. Holditch, Claire A. Schreiber, Ryan Nini, +7

Hypertension

HypertensionHeart FailureCardiovascular FunctionProgressive HypertensionBlood Pressure +20

Secretion of Glycosylated Pro–B-Type Natriuretic Peptide from Normal Cardiomyocytes

Jason M. Tonne, Jarryd M. Campbell, Alessandro Cataliotti, +7

Clinical Chemistry

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

Moustafa M. El Khatib, Toshie Sakuma, Jason M. Tonne, +5

Gene Therapy

Islet TransplantationAutoimmune DiseaseMedicineDiabetesImmunology +10

Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic <i>Glp-1</i> gene therapy

Jason M. Tonne, Toshie Sakuma, Michael Deeds, +4

Disease Models & Mechanisms