Optimization and Characterization of a Galleria mellonella Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against Streptococcus pneumoniae

Freya Cools, Eveline Torfs, Juliana Aizawa, +6

Frontiers in Microbiology

Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine

Pieter Claes, Davie Cappoen, Blaise Mavinga Mbala, +6

European Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineNatural Sciences +6

1,2,3,4,8,9,10,11-Octahydrobenzo[<i>j</i>]phenanthridine-7,12-diones as New Leads against <i>Mycobacterium tuberculosis</i>

Davie Cappoen, Pieter Claes, Jan Jacobs, +5

Journal of Medicinal Chemistry

Antimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryMycobacterium Tuberculosis +14

Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents

Davie Cappoen, Jan Jacobs, Tuyen Nguyen Van, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)BiochemistryStraightforward Palladium-mediated SynthesisAnti-tuberculosis Agents +8

Phytochemical and in vitro antimicrobial and genotoxic activity in the brown algae Dictyopteris membranacea

Najoua Akremi, Davie Cappoen, Roel Anthonissen, +2

South African Journal of Botany

Methanol/ch2cl2 FractionsAcetone FractionsDrug ResistanceGenotoxic ActivityToxicology +15

Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones

Maíra Bidart de Macedo, Roman Kimmel, Damijana Urankar, +13

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmaceutical ChemistryMedicineOrganic Chemistry +4

Anti-mycobacterial activity of 1,3-diaryltriazenes

Davie Cappoen, Jure Vajs, Cynthia Uythethofken, +8

European Journal of Medicinal Chemistry

MedicineAntibacterial AgentAntimicrobial ChemotherapyMicrobiologyAnti-mycobacterial Activity +4

Streptococcus pneumoniae galU gene mutation has a direct effect on biofilm growth, adherence and phagocytosis in vitro and pathogenicity in vivo

Freya Cools, Eveline Torfs, Bieke Vanhoutte, +8

Pathogens and Disease

Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1

Veronika Šlachtová, Marek Šebela, Eveline Torfs, +5

European Journal of Medicinal Chemistry

Pulmonary TuberculosisMedicineTuberculosisAntibacterial AgentAntimicrobial Chemotherapy +5

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models

Freija Van den Driessche, Bieke Vanhoutte, Gilles Brackman, +8

PLoS ONE

PathologyAntimicrobial ChemotherapyBacterial PathogensRespiratory InfectionInfection Control +14