Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Xuelian Xiong, Henry Kuang, Sahar Ansari, +27

Molecular Cell

Cell LineageSystems BiologySingle Cell SequencingMedicineLiver Physiology +10

Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment

Peng Zhang, Zhimin Chen, Henry Kuang, +14

Cell Metabolism

HepatologyLiver PhysiologyNeuregulin 4PathologyHepatology Inflammation +8

NRG1-Fc improves metabolic health via dual hepatic and central action

Peng Zhang, Henry Kuang, Yanlin He, +9

JCI Insight

Hepatic danger signaling triggers TREM2 ⁺ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation

Linkang Zhou, Xiaoxue Qiu, Ziyi Meng, +12

Science Translational Medicine

The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

Jin Lu, Shuang Han, Xue Lv, +23

Nature Communications

hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis

Jing Xiong, Tongyu Liu, Lin Mi, +5

Hepatology

Regulation of the DNA damage response on male meiotic sex chromosomes

Lin-Yu Lu, Yi Xiong, Henry Kuang, +2

Nature Communications

ChromatinGenome InstabilityInfertilityGeneticsMeiosis +9

Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader

Yidan Liu, Bin Zhang, Henry Kuang, +3

Journal of Biological Chemistry

Topoisomerase II Regulates the Maintenance of DNA Methylation

Lin‐Yu Lu, Henry Kuang, Gautam Korakavi, +1

Journal of Biological Chemistry

Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice

Tongyu Liu, Qiuyu Wang, Linkang Zhou, +7

Hepatology