Meha Patel

Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug Resistance

Mark Webber, Vito Ricci, Rebekah N. Whitehead et al. · mBio · 2013 · 87 citations · Full text

The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

Meha Patel, Liya Hu, V. Stojanoski et al. · Biochemistry · 2017 · 29 citations · Full text

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance

Meha Patel, Liya Hu, Cameron A. Brown et al. · Journal of Biological Chemistry · 2018 · 26 citations · Full text

Distinct Substitutions, Antimicrobial Resistance Gene, Antimicrobial Susceptibility +13

Characterization of the Global Stabilizing Substitution A77V and Its Role in the Evolution of CTX-M β-Lactamases

Meha Patel, Bartlomiej G. Fryszczyn, Timothy Palzkill · Antimicrobial Agents and Chemotherapy · 2015 · 24 citations · Full text

Klebsiella Pneumoniae, Molecular Biology, Confer Antibiotic Resistance +18

Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance

Cameron A. Brown, Liya Hu, Zhizeng Sun et al. · Journal of Biological Chemistry · 2020 · 24 citations · Full text