Mitochondrial metabolism promotes adaptation to proteotoxic stress

Peter Tsvetkov, Alexandre Detappe, Kai Cai, +16

Nature Chemical Biology

Mitochondrial BiogenesisMitochondrial FunctionPhysiologyMitochondrial MetabolismMetabolism +3

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

Yizhou He, Khyati Meghani, Marie‐Christine Caron, +16

Nature

ChromatinGenome InstabilityBrca1-deficient CellsChromatin StructureChromatin Remodeling +6

Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial

Shady Kotb, Alexandre Detappe, François Lux, +11

Theranostics

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

Sijumon Kunjachan, Alexandre Detappe, Rajiv Kumar, +8

Nano Letters

NanoparticlesEngineeringBiomedical EngineeringCancer PatientsNanomedicine +14

Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy

Alexandre Detappe, Eloïse Thomas, Mark W. Tibbitt, +7

Nano Letters

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma

Yuji Mishima, Bruno Paiva, Jiantao Shi, +23

Cell Reports

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

Pascal Drané, Marie-Eve Brault, Gaofeng Cui, +15

Nature

ChromatinTranscriptional RegulationSignaling PathwayChromatin StructureMolecular Regulation +11

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, +24

eLife

Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma

Alexandre Detappe, Hung V.‐T. Nguyen, Yivan Jiang, +10

Nature Nanotechnology

Hematological MalignancyMedicinePharmacologyImmune Checkpoint InhibitorMolecular Bottlebrush Prodrugs +9

Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab

Ahmed T. Kurdi, Siobhan Glavey, Natalie Bezman, +14

Molecular Cancer Therapeutics