Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling

Yibo Zuo, Qian Feng, Lincong Jin, +11

Nature Communications

ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP

Tingting Guo, Yibo Zuo, Liping Qian, +11

Nature Microbiology

Adp-ribosyltransferase Parp11Viral ReplicationMolecular VirologyInterferon Antiviral ResponseNatural Sciences +7

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Chen Huang, Aiwu Bian, Lian-Fang Yang, +9

Oncogene

Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense

Yukang Yuan, Ying Miao, Liping Qian, +15

Molecular Cell

Molecular VirologyImmunologyAntiviral ResponseVirologyVirus-host Interaction +3

Cycloheximide (CHX) Chase Assay to Examine Protein Half-life

Ying Miao, Qian Du, Yukang Yuan, +2

BIO-PROTOCOL

Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer

Chen Huang, Wenbo Zhou, Aiwu Bian, +11

Clinical Cancer Research

Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment

Chen Huang, Aiwu Bian, Wenbo Zhou, +11

ACS Central Science

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

Jin Liu, Lincong Jin, Xiangjie Chen, +12

PLoS Pathogens

Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment

Peng He, Aiwu Bian, Ying Miao, +10

Journal of Medicinal Chemistry

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr⁷⁰⁵/Ser⁷²⁷ Inhibitory Activity for Gastric Cancer Treatment

Peng He, Ying Miao, Yue Sun, +10

Journal of Medicinal Chemistry