Murine NKT cells produce Th17 cytokine interleukin-22

Megumi Goto, Masao Murakawa, Kumiko Kadoshima-Yamaoka, +4

Cellular Immunology

CytokineImmunologyAutoimmunityT Cell ImmunityMurine Nkt Cells +1

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

Kumiko Kadoshima-Yamaoka, Masao Murakawa, Megumi Goto, +11

Immunology Letters

InflammationIl-12-induced Ifn-γ ProductionImmune Cell DevelopmentMedicineImmune Regulation +10

G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions

Satoshi Muneoka, Megumi Goto, Kumiko Kadoshima-Yamaoka, +3

European Journal of Pharmacology

InflammationCytokineInflammatory DiseaseAutoimmune DiseaseInflammatory Conditions +9

Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte

Kumiko Kadoshima-Yamaoka, Masao Murakawa, Megumi Goto, +10

International Immunopharmacology

Phosphodiesterase 7Cytotoxic T LymphocyteInhibitor Asb16165Lymphocyte DevelopmentImmune Cell Development +8

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells

Megumi Goto, Masao Murakawa, Kumiko Kadoshima-Yamaoka, +10

Cellular Immunology

CytokineInhibitor Asb16165Immune Cell DevelopmentMedicineImmunology +7

Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion

Yohei Yoshihama, Hidenori Namiki, Taiga Kato, +14

Cancer Research

ApoptosisCell DeathPathologyTumor BiologyReceptor Tyrosine Kinase +16

Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo

Megumi Goto, Kumiko Kadoshima-Yamaoka, Masao Murakawa, +10

European Journal of Pharmacology

Inhibitor Asb16165AllergyMedicineCutaneous BiologyClinical Dermatology +5

ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-α level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice

Kumiko Kadoshima-Yamaoka, Megumi Goto, Masao Murakawa, +10

European Journal of Pharmacology

InflammationRheumatologyMedicineCutaneous BiologyImmunology +10

Inhibition of phosphodiesterase 7A ameliorates Concanavalin A-induced hepatitis in mice

Megumi Goto, Yoshitaka Tanaka, Masao Murakawa, +13

International Immunopharmacology

Phosphodiesterase 7AHepatologyViral HepatitisLiver PhysiologyMedicine +7

G Protein-Coupled Receptor 39 Agonist Improves Concanavalin A-Induced Hepatitis in Mice

Satoshi Muneoka, Megumi Goto, Tomonari Nishimura, +3

Biological and Pharmaceutical Bulletin

ImmunologyImmune RegulationCell DeathImmunologic MechanismImmunotherapeutics +25