Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

Miyako Masubuchi, Hirosato Ebiike, Ken‐ichi Kawasaki, +11

Bioorganic & Medicinal Chemistry

BiosynthesisAntifungal AgentBiochemistryBenzofuran Antifungal AgentsAntifungal Agents +6

The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR Inhibitor

Yoshito Nakanishi, Nukinori Akiyama, Toshiyuki Tsukaguchi, +11

Molecular Cancer Therapeutics

Radiation OncologyFgf ReceptorsNovel TherapyFgfr EnzymesMedicine +11

Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines.

Kun Wang, Hidetoshi Shindoh, Tomoaki Inoue, +1

The Journal of Toxicological Sciences

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

Ken‐ichi Kawasaki, Miyako Masubuchi, Kenji Morikami, +12

Bioorganic & Medicinal Chemistry Letters

BiosynthesisBioorganic ChemistryEngineeringAntifungal AgentAntifungal Agents +9

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2

Hirosato Ebiike, Miyako Masubuchi, Pingli Liu, +11

Bioorganic & Medicinal Chemistry Letters

BiosynthesisBioorganic ChemistryEngineeringAntifungal AgentAntifungal Agents +9

Discovery of [5-Amino-1-(2-methyl-3<i>H</i>-benzimidazol-5-yl)pyrazol-4-yl]-(1<i>H</i>-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Hirosato Ebiike, Naoki Taka, Masayuki Matsushita, +13

Journal of Medicinal Chemistry

Drug TargetChemoprevention StrategyHuman GrowthPharmacotherapyPharmaceutical Chemistry +23

Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications

Hidetoshi Shindoh, Kohnosuke Nakano, Takemi Yoshida, +1

The Journal of Toxicological Sciences

Chemoprevention StrategyCellular PharmacologyExperimental PharmacologyToxicological MechanismPre-clinical Pharmacology +22

RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS

Hidetoshi Shindoh, Akira Kawashima, N. Shishido, +3

The Journal of Toxicological Sciences

ImmunologyPharmacotherapyPhenethyl AnalogsOral Fluoropyrimidine CarbamateExperimental Pharmacology +15

Simple Evaluation Method for CYP3A4 Induction from Human Hepatocytes: The Relative Factor Approach with an Induction Detection Limit Concentration Based on the Emax Model

Shino Kuramoto, Motohiro Kato, Hidetoshi Shindoh, +3

Drug Metabolism and Disposition

Cassette Dosing Approach and Quantitative Structure−Pharmacokinetic Relationship Study of Antifungal <i>N</i>-Myristoyltransferase Inhibitors

Kiyoshi Hasegawa, Hidetoshi Shindoh, Yasuhiko Shiratori, +5

Journal of Chemical Information and Computer Sciences

Pharmaceutical ScienceBenzofuran DerivativesRat Elimination Half-lifeAntimicrobial ChemotherapyMolecular Pharmacology +15